Coumarin
General information:
| Withdrawn ID: | w180 |
|---|---|
| Canonical SMILES: | |
| Standard InChI: | |
| Standard InChIKey: | |
| ATC class(es): | B |
| Molecular Formula: | C9H6O2 |
| Molweight: | 146.143 |
Withdrawal information:
| Withdrawn due to drug safety reasons: | Yes |
|---|---|
| First approved: | 1868 |
| First death: | 1996 |
| First withdrawn: | 1996 |
| Last withdrawn: | 1996 |
| Reference: | https://www.ncbi.nlm.nih.gov/pubmed/11576099 |
Filtered ChEMBL targets:
| Target UniProtKB ID | Activity in nm | Target Name | Target gene |
|---|---|---|---|
| O43570 | 8900 | Carbonic anhydrase 12 | CAH12_HUMAN |
| P00915 | 3100 | Carbonic anhydrase 1 | CAH1_HUMAN |
| P00918 | 9200 | Carbonic anhydrase 2 | CAH2_HUMAN |
| P02545 | 794.3 | Prelamin-A/C | LMNA_HUMAN |
| P07451 | 5600 | Carbonic anhydrase 3 | CAH3_HUMAN |
| P22748 | 6800 | Carbonic anhydrase 4 | CAH4_HUMAN |
| P23280 | 2000 | Carbonic anhydrase 6 | CAH6_HUMAN |
| P35218 | 9400 | Carbonic anhydrase 5A, mitochondrial | CAH5A_HUMAN |
| P43166 | 3300 | Carbonic anhydrase 7 | CAH7_HUMAN |
| Q07820 | 4060 | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1_HUMAN |
| Q16790 | 9100 | Carbonic anhydrase 9 | CAH9_HUMAN |
| Q9ULX7 | 48 | Carbonic anhydrase 14 | CAH14_HUMAN |
| Q9Y2D0 | 5200 | Carbonic anhydrase 5B, mitochondrial | CAH5B_HUMAN |
Toxicity information:
| Toxicity class: | 4 |
|---|---|
| Toxicity type: | hepatic |
| LD50: | 623 mg/kg |
External links:
| ChEBML: | CHEMBL6466 |
|---|---|
| DrugBank: | DB04665 |